"Baby" hidden in "The Big Aunt"---endometrial stem cells

                                                 "Baby" hidden in "The Big Aunt"---endometrial stem cells
● It is not easy to love you.

Woman, treating the mood of aunt
Just like treating a dated person, he is afraid that he will not come, and he is afraid that he will come up with an upset. The pain 
of "wanting the heart and piercing the heart" can only be understood by a woman, and the nervousness of the nervousness is left and 
so on. Don't come, just buy a test strip and want to see if there is a winning...Did she suddenly come to the fore? Big aunt, it is 
not easy to say that it is not easy to love you. However, the big aunt who loves and hates the female compatriots can extract 
precious stem cells!Some friends will ask: Is there a stem cell in the aunt's disgusting thing? Are you picking up? What is it
? And listen to Xiaobian to give you one.

1.Endometrial stem cell

Endometrial stem cells (EnSCs) exist in the functional layer and basal layer of human endometrium. After the female matures, every 
other month or so, the endometrium undergoes an autonomous thickening and vascular proliferation. Usually 14 days after ovulation,
 if no egg is fertilized, the endometrium begins to fall off and is accompanied by bleeding, ie menstruation. The menstrual blood 
contains the exfoliated endometrium, which is rich in endometrial stem cells.A team study in Japan found that EnSCs accounted for 
about 2% of endometrial tissue, and they differentiated into intimal granule epithelium, mesenchymal and endothelial cells under 
different in vitro culture conditions, and may have the characteristics ofmesenchymal stem cells. Currently generally, EnSCs
Epithelial pluripotent stem cells and mesenchymal stem cells are included.

2. Endometrial stem cell source
There are different opinions on the source of endometrial stem cells. Some scholars believe that endometrial stem cells are derived
 from embryonic stem cells that remain in the inner membrane. Some scholars believe that the bone marrow-derived hematopoietic stem
 cells and mesenchymal stem cells are derived from circulation. Endothelial precursor cells. The first type: stem cells that remain
 in the embryonic period. That is, the female reproductive system in the embryonic period is derived from the mesoderm. As the 
embryonic tissue proliferates, some mesenchymal cells are transformed into epithelial cells, which form a body cavity epithelium, 
which then forms a mullerian tube or a secondary kidney tube. In the fetal period, the undifferentiated uterine epithelial 
invagination forms mesenchyme, the gland begins to develop, and the undifferentiated smooth muscle differentiates into the 
muscular layer. Some scholars believe that in adulthood, some fetal-derived Müllerian or accessory renal tubular epithelial 
and mesenchymal stem cells are left in the endometrium and play a role in the tissue cycle regeneration of the menstrual cycle, 
ie EnSCs may be A product left over from the fetal stem cell stage.Second: the bone marrow-derived hematopoietic stem cells in 
the circulation are transformed. Bone marrow-derived hematopoietic stem cells are involved in the blood circulation, and 
endometrial stem cells are most likely derived from bone marrow hematopoietic stem cells. A team at Yale once detected 
endometrial stem cells from donors in the endometrium of bone marrow transplant recipients, so it is speculated that the 
source of EnSCs is bone marrow.
3. Advantages of endometrial stem cells

(1) opening up a new storage route for women who missed the storage of umbilical cord, placenta, and deciduous teeth; 
(2) have a better effect in the prevention and treatment of endocrine system diseases; 
(3) It is very convenient to take materials. It can be collected non-invasively using sanitary napkins and moon cups without 
the help of professionals. 
(4) can be obtained periodically; 
(5) The proliferation activity is strong, so that a larger number of cells can be stored under the same generation conditions; 
(6) Low immunogenicity and use by family members without matching. 
(7) Collection security Extracted from the endometrial tissue after menstrual blood, does not have any adverse effects on women, 
turning waste into treasure.

4. Clinical application value of endometrial stem cells

(1) Application of endometrial stem cells in regenerative medicine: Adult stem cells are highly plastic, and their directed 
differentiation is closely related to functional repair of tissues;
(2) Endometrial stem cells have broad clinical application prospects in tissue regeneration therapy because of their convenient 
materials and biological characteristics.
(3) Research has been done for the treatment of other diseases
a In a mouse model of Parkinson's disease, endometrial stem cells can be differentiated in vitro into dopaminergic neuron cells 
that secrete dopamine and have electrophysiological properties of central neurons;
b Endometrial stem cells have shown therapeutic potential in diseases such as diabetes and cirrhosis;
c Endometrial stem cells have been used in multiple stage sclerosis and chronic heart failure in Phase I and Phase II clinical 
trials. There are no reports of adverse reactions such as immune rejection.
d Endometrial stem cells differentiate into striated muscle cardiomyocytes in the heart of myocardial ischemia, and are expected 
to be used for the treatment of myocardial infarction.
e Studies have used endometrial stem cells for the treatment of pelvic floor related diseases, such as urinary incontinence, 
incontinence and pelvic organ prolapse, as well as uterine infertility such as intrauterine adhesions, to help improve women's reproductive system function.
f Endometrial stem cells promote angiogenesis and can be used to treat burns, and so on.

5. Preparation and storage of endometrial stem cells

You may have questions about how to obtain endometrial stem cells. A woman's menstrual blood volume is about 70ml, and the amount 
of stem cells is very small. How to store it? In fact, the material is very convenient to use, the use of the moon cup can be 
non-invasive collection, but also through simple curettage, hysteroscopic surgery, etc.; endometrial stem cells have strong 
proliferation, can be amplified by in vitro culture, and thus can be stored A lot of cells. Endometrial stem cells are stored 
in the same manner as normal stem cells and are stored in liquid nitrogen at -196 °C after preparation.