Endometrial stem cells: female anti-aid weapon
Regenerative medicine requires very dry seed cells, and the female uterus is the soil that regenerates fresh cells. Studies at home and abroad have shown that regenerative cells are produced every month in women and are excreted with menstrual blood. This is endometrial stem cells.
As early as the end of 2013, the mainland national high-tech enterprise Shunyi Cell Biotechnology (Tianjin) Co., Ltd. (hereinafter referred to as Shunyi Bio) was approved for the “12th Five-Year Plan” major science and technology project in the mainland, and with Peking Union Medical College Hospital and Tianjin Medical College. The University General Hospital and the Tianjin Central Maternity Hospital jointly undertook the 2014 new drug creation project “Pre-clinical and clinical studies of endometrial regenerative cells for the treatment of premature ovarian failure”. In the past two years, this research has made breakthroughs in the key process technologies of industrialization such as large-scale expansion of stem cells, pharmaceutical preparations and cold chain transportation, and obtained a number of patents. On the occasion of the upcoming completion of the major national stem cell project in mainland China, on November 27th, Shunyi Bio and Beijing Kairunting Medical Investment Management Co., Ltd. held a seminar on the special application results of endometrial and adipose stem cells in Beijing, and attended the meeting. The show shows the mature "landing" endometrial stem cell storage technology.
Human's most abundant stem cell resources
do you know? The "big aunt" that the majority of female compatriots love and hate is not the waste that is excreted in vain, but the baby who treats the disease, because it can also extract precious stem cells - endometrial stem cells. Endometrial stem cells are high-proliferation stem cells found in the menstrual blood of women. They contain stem cell markers such as OCT-4, SSE-4 and CD117, and have very similar regenerative capacity with embryonic stem cells and bone marrow stem cells. It is also capable of differentiating into other types of healthy cells and has great potential in regenerative medicine.
According to Zhu Ze, head of the biotechnology team, the endometrial stem cells are undifferentiated endometrial cells with self-renewal, multi-directional differentiation and unlimited proliferation, including a very small number of endometrial epithelial stem cells and endometrium. Stem cells and most endometrial endothelial progenitor cells. "The differentiation ability of endometrial stem cells is higher than that of mesenchymal stem cells, and the dryness is even higher than that of the Nobel Prize-winning IPS pluripotent stem cells, which has a strong ability to repair and regenerate. " Zhu Ze told reporters of the Journal of Chinese Academy of Sciences that the palace Membrane stem cells are self-renewing in a xenograft system, have a high proliferative capacity and a certain differentiation potential, and are pluripotent stem cells in accordance with the characteristics of stem cells.
Specifically, Zhu Ze said that the number of endometrial stem cells is 30 times that of bone marrow stem cells, so menstrual blood is expected to become the world's largest source of stem cells; strong proliferation in vitro, once every 24 to 36 hours, can proliferate 390 times Passage up to 50 times, and cord blood stem cells can only be passaged up to 12 times at most; differentiation potential is large, can be differentiated into at least 5 known cell types; low immunogenicity, is a type of immunodeficiency cells, no need After strict pairing, allogeneic transplantation has no immune rejection or weak response; the collection method is simple and is not restricted by moral, ethical and legal issues.
Compared with stem cells from other sources, endometrial stem cells have many advantages such as strong proliferative ability, no chromosomal variation, and no tumorigenesis.
Broad prospects in the field of biomedical anti-aging
Nowadays, stem cell therapy is another medical revolution after drug therapy and surgery. It opens up new ideas for the treatment of human diseases, and the unique properties of endometrial stem cells (both adult and embryonic) also mean It has great potential in regenerative medicine. At present, stem cells can regenerate the body's largest organ, the skin, which has become an indisputable fact. It achieves anti-aging through two mechanisms: one is cell replacement, that is, stem cells are automatically recognized and migrated to the site of cell damage after entering the body, and mitosis The new cells, that is, the "homing effect" in stem cell theory; the second is that the stem cells input into the body secrete many cytokines to function as nutrients and repair the damage of the body.
Endometrial stem cells have high clinical value in the field of anti-aging, and premature ovarian failure is a typical case. Premature ovarian failure refers to a disease characterized by ovarian dysfunction, infertility, estrogen deficiency, and elevated gonadotropin levels before the age of 40, and transvaginal endometrial stem cells through the bloodstream will be expected to treat premature ovarian failure. In addition, Zhu Ze said that endometrial stem cells can also be used for genetic testing and cosmetic customization. Shunyi Bio is cooperating with the Chinese Academy of Medical Sciences, Tianjin Pharmaceutical Research Institute, Peking Union Medical College Hospital and other units to actively carry out anti-aging and beauty treatment. Related research on wrinkles and other aspects. In addition, in view of the potential of endometrial stem cells, the future can also be treated for endometrial renewal and endometriosis, infertility, endometritis and some metabolic diseases such as diabetes, cardiovascular disease, nervous system damage, etc. .